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KMID : 0385520100230060572
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Analytical Science & Technology
2010 Volume.23 No. 6 p.572 ~ p.578
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Simultaneous analysis and occurrences of six pharmaceuticals in surface water by LC/ESI-MS/MS
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Kim Byung-Joo
Myung Seung-Woon
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Abstract
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In this study, sample preparation and analytical method for the monitoring of six pharmaceuticals (cephradine, cefadroxil, penicillin G, vancomycin, iopromide, and fenbendazole) in surface water was investigated. The extraction/clean-up and concentrating of pharmaceuticals from surface water were performed by HLB (Hydrophilic-Lipophilic Balanced) cartridge. The method allows for the simultaneous determination of six pharmaceuticals by HPLC/ESI(+)-MS/MS. Recoveries of the pharmaceutical were between 71.1 to 92.6% (except fenbendazole) and the overall variability of the method was below 11.2% (RSD). The calibration curves for the pharmaceuticals from blank surface water showed good linearities (above r² = 0.99) in the concentration range of 0.007~1.2 ng/mL. The limit of detection (LOD) and the limit of quantification (LOQ) were 7.2~128.7 pg/mL and 23.8~429.1 pg/mL, respectively. The present analytical method can be useful for monitoring residual pharmaceuticals in surface water and other aquatic samples. High concentrations of iopromide and fenbendazole were detected in a few samples of surface water.
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KEYWORD
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pharmaceuticals, surface water, chemical analysis, LC/ESI-MS/MS
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